Lactic Acidosis: High-Dose or Low-Dose Bicarbonate Therapy?

Lactic acidosis: high-dose or low-dose bicarbonate therapy?

occurs intracellularly, extracellularly, and in the cerebrospinal fluid (CSF). Adding sodium bicarbonate to the extracellular fluid causes a decrease in hydrogen ions with subsequent increase in carbon dioxide (CO2) concentration. Since CO2) but not bicarbonate, readily diffuses across cell membranes and into the CSF, this leads to an increase in intracellular and CSF CO2 concentration, with co...

Sodium bicarbonate controversy in lactic acidosis.

1 Barst RJ. Experience and reason [editorial]. Chest 2000; 117:2–5 2 Klings ES, Hill NS, Ieong MH, et al. Systemic sclerosisassociated pulmonary hypertension: shortand long-term effects of epoprostenol (prostacyclin). Arthritis Rheum 1999; 42:2638–2645 3 Klings ES, Ieong MH, Simms RW, et al. Long-term intravenous epoprostenol therapy for pulmonary hypertension associated with systemic sclerosis...

Peri-Operative High-Dose v Post-Operative Low Dose Steroid Therapy in the Management of Biliary Atresia: a Preliminary Report

Background: The use of high-dose steroid therapy peri portoenterostomy may have a positive impact on the frequency of cholangitis and survival rate. Methods: A prospective study was conducted on two groups of patients (less than three months of age) suffering from biliary atresia from 1999 to 2005. The patients in group I (G I) were managed peri-operatively by high-dose methylprednisolone while...

Low dose, high dose, or no dose: better prescribing of cholinesterase inhibitors for Alzheimer's disease.

Heparin for coronary angioplasty: high dose, low dose, or no dose?